Sky Girls (スカイガールズ Sukai Gāruzu?) began as a single episode OVA anime by Konami, directed by Yoshiaki Iwasaki and animated by J.C.Staff. The 30 minute episode was released in Japan on August 25, 2006. A television adaptation of Sky Girls started on July 5, 2007, and ended on January 11, 2008.

- 2071 CE Since their sudden appearance, the mechanical cell clusters, known as the WORMs, begin sweeping away the human race on a massive scale.
- 2073 CE After losing one-third of the population in the war with the WORMs, humanity overcame their national differences and united behind a single force.
- 2074 CE Not being able to turn the situation in their favor, humanity decided to permit the use of weapons of mass destruction. And they succeeded in the annihilation of the WORMs. However, the price they paid was enormous. All the major continents were broken apart. Antarctica disappeared, and half of the remaining land mass was submerged. The largest damage this war caused was the loss of 90% of all military-age personnel, namely men in their twenties and thirties.
- 2086 CE The WORMs, once thought to have been eliminated, began their activities again.

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